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Veenat 400mg Tablet (Imatinib) is indicated for the treatment of various conditions in adults, children, and adolescents, including:
- Chronic Myeloid Leukaemia (CML)
- Philadelphia Chromosome Positive Acute Lymphoblastic Leukaemia (Ph-positive ALL)
Additionally, Veenat 400mg Tablet is used specifically in adults for the treatment of:
- Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
- Hyper-eosinophilic syndrome (HES) and/or Chronic Eosinophilic Leukaemia (CEL)
- Gastrointestinal Stromal Tumours (GIST)
- Dermatofibrosarcoma Protuberans (DFSP)
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✅ Description:
Veenat 400mg Tablet, containing Imatinib, a Tyrosine Kinase Inhibitor, is utilized to treat various conditions in adults, children, and adolescents, including:
- Chronic Myeloid Leukaemia (CML)
- Philadelphia Chromosome Positive Acute Lymphoblastic Leukaemia (Ph-positive ALL)
- Myelodysplastic/Myeloproliferative Diseases (MDS/MPD)
- Hyper Eosinophilic Syndrome (HES) and/or Chronic Eosinophilic Leukaemia (CEL)
- Gastrointestinal Stromal Tumours (GIST)
- Dermatofibrosarcoma Protuberans (DFSP)
Before initiating Veenat 400mg Tablet, disclose any history of kidney, liver, or heart issues, hepatitis B infection, or thrombotic microangiopathy to your doctor.
Pregnant and breastfeeding women should avoid VEENAT 400MG TABLET unless specifically advised by a physician. Caution is warranted in children, adolescents, and elderly individuals (aged 65 years and above).
Safety Advices
UNSAFE
Consult your doctor before consuming alcohol with Veenat 400.
UNSAFE
Consult your doctor before using Veenat 400 during pregnancy as it may pose risks to the developing baby.
UNSAFE
Avoid breastfeeding while using Veenat 400 as it may harm the baby.
CAUTION
Veenat 400 may cause side effects that could impair your ability to drive.
CONSULT YOUR DOCTOR
Use Veenat 400 with caution in patients with kidney disease. Dose adjustment may be necessary.
CONSULT YOUR DOCTOR
Use Veenat 400 with caution in patients with severe liver disease. Dose adjustment may be necessary.
✔️ Uses of Veenat 400mg Tablet
For the treatment of cancer growth in blood, stomach, or intestine.
✔️ How does Veenat 400mg Tablet work?
Inhibits the BCR-ABL tyrosine kinase, blocking proliferation and inducing apoptosis in cancer cells.
✔️ Side Effects of Veenat 400mg Tablet
Common side effects include edema, neutropenia, nausea, muscle cramps, musculoskeletal pain, thrombocytopenia, rash, fatigue, diarrhea, headache, abdominal pain, and myalgia, among others.
✔️ Quick Suggestions:
- Take Veenat 400 mg Tablet with a meal to avoid stomach irritation
- Take Veenat 400 mg Tablet exactly as prescribed by your doctor.
- Avoid taking this medicine in larger or smaller quantities than recommended.
- Avoid the discontinuation of this medicine without consulting your doctor.
- You may require frequent blood tests and liver function tests while taking this medicine.
- You may also require frequent follow-ups with your doctor to check the progress of treatment.
- Avoid the exposure to direct sunlight.
- Use protective clothing and sunscreen while going out in the sun.
✔️ Indications:
Used in the treatment of chronic myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic disease, hypereosinophilic syndrome, mastocytosis, dermatofibrosarcoma protuberans, and malignant gastrointestinal stromal tumors.
✔️ Pharmacology
Veenat 400mg Tablet is classified as a protein-tyrosine kinase inhibitor. Tyrosine kinases are enzymes that play a crucial role in the signaling pathways involved in cell growth and proliferation. In cancer cells, these pathways are often dysregulated, leading to uncontrolled cell growth and tumor formation.
Veenat 400mg Tablet works by inhibiting the activity of tyrosine kinases, specifically targeting the abnormal enzyme produced by cancer cells. By blocking these enzymes, Veenat 400mg Tablet interferes with the signaling pathways that promote cancer cell growth and proliferation. This ultimately leads to the suppression of cancer cell growth and may result in tumor shrinkage or slowing of disease progression.
In summary, Veenat 400mg Tablet acts by inhibiting tyrosine kinases, which are essential for the growth and survival of cancer cells, thereby helping to control the progression of cancer.
✔️ Dosage & Administration:
- Adult Dose: Dosage varies depending on the condition being treated, ranging from 400mg to 600mg orally once or twice daily.
- Child Dose: Dosage depends on the child's age and weight, ranging from 340mg/m²/day to 600mg/day orally.
Take with food and a large glass of water.
✔️ Interaction
Interactions with CYP3A4 inhibitors and inducers may affect serum levels of various drugs metabolized by CYP3A4, CYP2C9, and CYP2D6.
✔️ Contraindications
Avoid in case of hypersensitivity and during lactation.
✔️ Pregnancy & Lactation
- It is not recommended to use this medication during pregnancy unless deemed essential by a doctor, with the potential risks justifying the benefits.
- For women of childbearing age taking this medication, effective contraception should be used, both during treatment and for approximately 15 days after discontinuing the medication.
- Regarding breastfeeding, this medication should not be taken while breastfeeding and for about 15 days after stopping it.
✔️ Precautions & Warnings
Monitor for signs of severe fluid retention, cardiac disease, and increased risk for congestive heart failure. Regularly monitor CBC, liver function tests, and renal function.
✔️ Storage Conditions
- Keep Veenat 400mg Tablet out of reach of children
- Store Veenat 400mg Tablet at room temperature
✔️
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
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lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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